Enantioselective Addition of Diethylzinc to Aldehydes in the Presence of Chiral Titanium Reagent Modified withN-Sulfonylated Amino Alcohol
- 1 January 1992
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1992 (07) , 573-574
- https://doi.org/10.1055/s-1992-21419
Abstract
Titanium(IV) isopropoxide modified with (1S,2R)-2-(p-methoxyphenylsulfonylamino)-1-phenylpropanol (9), was found to be an effective catalyst for enantioselective addition of diethylzinc to aldehydes. For example, benzaldehyde was converted into (S)-1-phenylpropanol in 97% enantiomeric excess.Keywords
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