Synthesis of Chitooligosaccharide Derivatives by Condensation Polymerization

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Abstract
Oligomerization of mono- and oligosaccharide units can be an interesting methodology for synthesis of homooligosaccharides and oligosaccharides having repeating units, respectively. Recently, chitooligosaccharides, especially the hexamer, were shown to have an antitumor effect,2 suppress metastasis3 and protect against microbial infection.4 For the synthesis of these oligomers the ring-opening polymerization of such monomers as 1,6-anhydro5 and 1,2-cyano-ethylidene6 derivatives, which are the effective monomers for polycondensation, cannot be used.