Molecular Modeling-guided Mutagenesis of the Extracellular Part of gp130 Leads to the Identification of Contact Sites in the Interleukin-6 (IL-6)·IL-6 receptor·gp130 Complex
Open Access
- 1 September 1997
- journal article
- Published by Elsevier in Journal of Biological Chemistry
- Vol. 272 (38) , 23748-23757
- https://doi.org/10.1074/jbc.272.38.23748
Abstract
No abstract availableKeywords
This publication has 37 references indexed in Scilit:
- Participation of Two Ser‐Ser‐Phe‐Tyr Repeats in Interleukin‐6 (IL‐6)‐Binding Sites of the Human IL‐6 ReceptorEuropean Journal of Biochemistry, 1996
- Differential Activation of Acute Phase Response Factor/STAT3 and STAT1 via the Cytoplasmic Domain of the Interleukin 6 Signal Transducer gp130Journal of Biological Chemistry, 1996
- Interleukin‐6 signal transducer gp130 has specific binding sites for different cytokines as determined by antagonistic and agonistic anti‐gp130 monoclonal antibodiesEuropean Journal of Immunology, 1995
- Requirement of Serine Phosphorylation for Formation of STAT-Promoter ComplexesScience, 1995
- Interleukin‐6‐induced serine phosphorylation of transcription factor APRF: evidence for a role in interleukin‐6 target gene inductionFEBS Letters, 1995
- The membrane distal half of gp130 is responsible for the formation of a ternary complex with IL‐6 and the IL‐6 receptorFEBS Letters, 1995
- IL-6-Induced Homodimerization of gp130 and Associated Activation of a Tyrosine KinaseScience, 1993
- Single‐step purification and structural characterization of human interleukin‐6 produced in Esherichia coli From a T7 RNA polymerase expression vectorEuropean Journal of Biochemistry, 1991
- Molecular cloning and expression of an IL-6 signal transducer, gp130Cell, 1990
- Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130Cell, 1989