Infertility Induced in Mice by a Single Injection of Testosterone Propionate.

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Abstract
Mice 5, 10 and 20 days of age were given a single 1-mg subcut. injn. of testosterone propionate. When 90 days old, fertility of the treated mice was compared with littermate controls. No litters were obtained with mice treated at 5 days of age despite 100 days in breeding, whereas all control mice dropped litters 22-40 days after being placed with the male. Fertility of mice treated when 20 days old was not influenced, and mice treated at 10 days of age assumed an intermediate position, 4 of 12 being sterile. Ovaries of infertile mice contained few follicles, no corpora lutea and increased sudanophilia in the stroma.

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