ORAL PREMEDICATION IN CHILDREN WITH TRIMEPRAZINE: The Effect of varying Dosage and Timing

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Abstract
In the belief that both dosage and timing of premedication may be important, a double blind trial was carried out on 484 children undergoing adenotonsillectomy receiving trimeprazine with hyoscine according to four differing methods within the limits suggested by the manufacturers' instructions. Thus trimeprazine was given in doses of 1 or 2 mg/lb. (2.2 or 4.4 mg/kg), 1 or 2 hours pre-operatively. The most intense action of the drug was evident when the stronger dose was given 2 hours before operation. However, this was associated with a comparative deterioration in behaviour of the children in the anaesthetic room and a higher frequency of undue postoperative pallor. Possible advantages of the more intense action of trimeprazine are salivary suppression and amnesia. Postoperative vomiting was infrequent with all four methods of premedication. A plea is made for the more critical evaluation of premedicant drugs.

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