A New HTLV-III/LAV Protein Encoded by a Gene Found in Cytopathic Retroviruses
- 28 March 1986
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 231 (4745) , 1546-1549
- https://doi.org/10.1126/science.3006243
Abstract
The DNA of the HTLV-III/LAV group of retroviruses contains certain additional open reading frames that are not found in typical avian or mammalian retroviruses. The role of these sequences in encoding for gene products that may be related to pathogenesis remains to be resolved. An open reading frame whose 5' end overlaps with the pol gene, but is unrelated to the env gene, has been observed in HTLV-III/LAV and visna virus, both cytopathic mammalian retroviruses. Evidence presented here shows that this open reading frame is a bona fide coding sequence of HTLV-III/LAV and that its product, a protein with a molecular weight of 23,000, induces antibody production in the natural course of infection.This publication has 27 references indexed in Scilit:
- Location of the Trans -Activating Region on the Genome of Human T-Cell Lymphotropic Virus Type IIIScience, 1985
- Trans -Activator Gene of Human T-Lymphotropic Virus Type III (HTLV-III)Science, 1985
- Major Glycoprotein Antigens That Induce Antibodies in AIDS Patients Are Encoded by HTLV-IIIScience, 1985
- Expression in Escherichia coli of Open Reading Frame Gene Segments of HTLV-IIIScience, 1985
- Complete nucleotide sequence of the AIDS virus, HTLV-IIINature, 1985
- Aetiology of AIDS—antibodies to human T-cell leukaemia virus (type III) in haemophiliacsNature, 1984
- Serological Analysis of a Subgroup of Human T-Lymphotropic Retroviruses (HTLV-III) Associated with AIDSScience, 1984
- Frequent Detection and Isolation of Cytopathic Retroviruses (HTLV-III) from Patients with AIDS and at Risk for AIDSScience, 1984
- Detection, Isolation, and Continuous Production of Cytopathic Retroviruses (HTLV-III) from Patients with AIDS and Pre-AIDSScience, 1984
- Isolation of a T-Lymphotropic Retrovirus from a Patient at Risk for Acquired Immune Deficiency Syndrome (AIDS)Science, 1983