Synergy of amoxycillin combined with clavulanate and YTR 830 in experimental infections in mice

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Abstract
YTR 830, a new β-lactamase inhibitor, is synergistic with amoxycillin in vitro against a number of β-lactamase-producing organisms. The combination of amoxycillinYTR 830 was compared to amoxycillin-clavulanate in the treatment of experimental Staphylococcus aureus, Citrobacter freundii and Proteus mirabilis infections in mice. Both combinations were synergistic with amoxycillin against all three test organisms. The amoxycillin-clavulanate combination was superior against S. aureus and C. freundii while amoxycillin-YTR 830 was more effective against P. mirabilis. The difference in efficacy between the two drug combinations appears to relate to the degree of protection afforded the animals by the β-lactamase inhibitor alone. YTR 830 is a promising new agent and should undergo further investigation.

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