The effect of different nutritional feeds on the postprandial glucose response in healthy volunteers and patients with type II diabetes

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Abstract
Objective: Assessment of postprandial glycaemic response to four nutritional feeds with different macronutrient and fibre composition. Design: A randomized, double-blind, crossover study. Setting: University of Maastricht, the Netherlands. Subjects: A total of 10 healthy volunteers and 10 patients with type II diabetes. Interventions: Subjects received 200 kcal of four enteral nutrition products (two standard products and two diabetes-specific products). Fasting and postprandial plasma glucose were measured for 2 h. Peak glucose level and area under the curve were calculated. Results: In healthy volunteers and diabetic patients, the feed with a low carbohydrate (CHO), high monounsaturated fatty acid (MUFA) and high fibre content significantly decreased peak glucose concentration and area under the curve compared to the feeds with standard composition. Conclusions: Special feeds with a low CHO, high MUFA and high fibre content improve glycaemic balance and therefore should be considered in diabetic patients who are in need of nutritional support. Sponsorship: Numico Research BV, The Netherlands.