Effect of prothrombin complex concentrates on factor VIII inhibitor levels
Open Access
- 1 December 1979
- journal article
- Published by American Society of Hematology in Blood
- Vol. 54 (6) , 1358-1368
- https://doi.org/10.1182/blood.v54.6.1358.1358
Abstract
Factor VIII inhibitor levels were measured on 261 occasions in 76 hemophilia-A inhibitor patients before and after prothrombin complex concentrate infusion at 13 treatment centers. A rise in inhibitor level to at least twice the pretreatment value occurred in 35 treatment episodes (13.5%), in 27 patients (36%). In 16 patients (21%), such an anamnestic immune response occurred with the first treatment. Factors predisposing to anamnestic responses may include patient idiosyncrasy, low pretreatment inhibitor levels, and exposure to concentrate over several days.Keywords
This publication has 0 references indexed in Scilit: