Non-specificity of the Divalent Cation Capable of Restoring Normal Intestinal Permeability after Chelation Depletion.

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Abstract
Removal of divalent cations, Ca and Mg, via chelation with disodiumdihydrogenethylenediaminetetraacetate (Na2H2 EDTA) increases the intestinal permeability to phenol red 2.7 fold over normal in an in situ rat preparation. Normal permeability could be reinstated with any of the alkaline earth metals tested. Each of these metals is capable of reinstating normal permeability at a minimal concentration. These minimum levels of replacement for each ion are in accord with the position of the element in the periodic table, Be++< Mg++< Ca++<. Sr++< Ba++. The relationship between minimal replacement concentration and charge density appears to indicate that a physical property of these ions is involved in the restoration of permeability, as opposed to a specific biochemical characteristic of a particular ionic species.