Biochemical studies of toxic agents. 4. A study of ethereal sulphate formation in vivo using radioactive sulphur

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Abstract
Quantitative studies were made of the excretion of S35 in the inorganic and total sulfate fractions of the urine of rats following the intraperit. injn. of Na2S35O4 alone or simultaneously with 2-naphthylamine by stomach tube or by subcut. injn. When Na2S35O4 was given alone, 5-6 % of the S35 administered was excreted in the ethereal sulfate fraction of the urine in the 72 hrs. after dosing. When 2-naphthylamine was also administered 44-48% of the S35 administered was excreted in the increased ethereal sulfate fraction in the 72 hrs. after dosing. From the urine of rats injd. intraperit. with Na2S35O4 and given 2-naphthylamine by subcut. injn. at the same time, radioactive 2-amino-l-naphthylsulfuric acid was isolated. Analogous studies with 2-naphthol yielded radioactive 2-naphthylsulfuric acid (as the p-toluidine salt). Hence intraperitoneally administered Na2SO4 can participate in the formation of ethereal sulfates in the rat.