INFLUENCE OF ADRENAL CORTICAL STEROIDS UPON THE BLOOD PRESSURE AND THE RATE OF PROGRESSION OF EXPERIMENTAL NEPHRITIS IN RATS
- 1 May 1946
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 38 (5) , 315-324
- https://doi.org/10.1210/endo-38-5-315
Abstract
IN RECENT YEARS it has been demonstrated that long continued administration of desoxycorticosterone acetate (DCA) may induce a rise in blood pressure in patients with or without disease of the adrenal glands (Loeb, Atchley, Ferrebee and Ragan, 1939; Ferrebee, Ragan, Atchley and Loeb, 1939; Thorn, Dorrance and Day, 1942; Engel, Cohn and Soffer, 1942; Roth, Robinson and Wilder, 1943; Perera, Knowlton, Lowell and Loeb, 1944) as well as in normal dogs and rats (Kuhlmann, Ragan, Ferrebee, Atchley and Loeb, 1939; Grollman, Harrison and Williams, 1940; Selye, Hall and Rowley, 1943). In animals treated with DCA, this hypertension is often associated with evidences of renal damage (Selye, Hall and Rowley, 1943; Selye and Hall, 1943; Selye and Pentz, 1943). No similar effect on blood pressure has been reported following prolonged treatment with adrenal cortical extract (ACE), Grollman, Harrison and Williams (1940).Keywords
This publication has 1 reference indexed in Scilit:
- ADDISON'S DISEASE: EVALUATION OF SYNTHETIC DESOXYCORTICOSTERONE ACETATE THERAPY IN 158 PATIENTSAnnals of Internal Medicine, 1942