Histone Regulation of Lactic Dehydrogenase in Embryonic Chick Brain Tissue
- 9 April 1965
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 148 (3667) , 242-244
- https://doi.org/10.1126/science.148.3667.242
Abstract
Histone, when added at low concentrations to cultures of embryonic chick brain tissue, causes an inductive response in lactic dehydrogenase activity, whereas at higher concentrations of histone the response is repressive. This control is shown to operate by altering protein synthesis. Thus, histones exercise a primary regulatory function in the chick. Unlike lactic dehydrogenase, acetylcholine esterase is stable in this system and is not affected by histones or inhibitors of protein synthesis.Keywords
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