A circulating anticoagulant in gamma-1A-multiple myeloma: its modification by penicillin.

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Abstract
A patient with myeloma of the gamma-1A/demonstrated a defect in the first stage of clotting, i.e. an inhibitor against anti-hemophiliac globulin. This inhibitor could be reversed by penicillin in-vivo as well as in-vitro by penicillamine. The offending protein was isolated by starch block and continuous flow electrophoresis from the patient''s plasma. Specific antiserum against gamma-lA globulin was able to reverse the clotting defect in the patient''s plasma. It was postulated that disulfide bond reduction disrupted the interaction between the myeloma and anti-hemophiliac globulin proteins.