α2-Adrenoceptor-mediated Inhibitory and Excitatory Effects of Detomidine on Rat Gastric Acid Secretion

Publisher Website
Google Scholar
Abstract
— The effects of the selective α2‐adrenoceptor agonist detomidine on gastric acid secretion from pylorus‐ligated and stomach‐perfused rats have been investigated. In pylorus‐ligated rats i.p. injection of detomidine markedly inhibited acid secretion, this effect being prevented by yohimbine or idazoxan. Under the same conditions, idazoxan significantly increased secretion in a dose‐independent fashion. In non‐vagotomized and vagotomized stomach‐perfused rats i.p. detomidine stimulated acid secretion: this excitatory effect was antagonized by idazoxan. The present results suggest that both inhibitory and excitatory gastric secretory effects of detomidine are mediated by α2‐adrenoceptors on cholinergic and adrenergic nerves, respectively. The stimulant activity of idazoxan on gastric secretion from pylorus‐ligated rats may be interpreted in terms of increased excitatory vagal tone following the blockade of inhibitory α2‐adrenoceptors.

This publication has 23 references indexed in Scilit: