Genetic implications for long-term survivors of childhood cancer
- 15 May 1993
- Vol. 71 (S10) , 3435-3440
- https://doi.org/10.1002/1097-0142(19930515)71:10+<3435::aid-cncr2820711750>3.0.co;2-h
Abstract
The author reviews current findings regarding inherited cancer predisposition and childhood cancer and proposes development of genetic services for long-term survivors of childhood cancer. Overall, it is suggested that relatively rare germline mutations in the tumor suppressor genes, Rb, p53, and WT1, may have important implications for long-term survivors relevant to familial cancer, second malignant neoplasms, and developmental disorders. Although continued research clearly is needed, planning for genetic services for long-term survivors should begin now.Keywords
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