Functional Amyloids As Natural Storage of Peptide Hormones in Pituitary Secretory Granules
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- 17 July 2009
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 325 (5938) , 328-332
- https://doi.org/10.1126/science.1173155
Abstract
Plethora of Secretory Amyloids: Protein aggregation and the formation of amyloids are associated with several dozen pathological conditions in humans, including Alzheimer's disease, Parkinson's disease, and type II diabetes. In addition, a few functional amyloid systems are known: the prions of fungi, the bacterial protein curli, the protein of chorion of the eggshell of silkworm, and the amyloid protein Pmel-17 involved in mammalian skin pigmentation. Now Maji et al. (p. 328 , published online 18 June) propose that endocrine hormone peptides and proteins are stored in an amyloid-like state in secretory granules. Thus, the amyloid fold may represent a fundamental, ancient, and evolutionarily conserved protein structural motif that is capable of performing a wide variety of functions contributing to normal cell and tissue physiology.Keywords
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