Increased Mutation Frequencies in Escherichia coli Isolates Harboring Extended-Spectrum β-Lactamases
Open Access
- 1 November 2005
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 49 (11) , 4754-4756
- https://doi.org/10.1128/aac.49.11.4754-4756.2005
Abstract
Hypermutable (mutation frequency [ f ], ≥4 × 10 −8 ) Escherichia coli strains were more frequently found (43%) in a collection of 89 extended-spectrum β-lactamase (ESBL)-producing isolates from different patients (77 pulsed-field gel electrophoresis clones, 12 ESBL types) than in non-ESBL E. coli (26%) strains ( P = 0.03). Among urinary tract isolates, the frequency of hypermutation was 40% in ESBL versus 26% in non-ESBL isolates ( P = 0.03).Keywords
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