X-Ray Diffraction Studies of Tubules Formed from a Diacetylenic Phosphocholine Lipid

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Abstract
The diacetylenic phosphocholine lipid 1,2-bis(10, 12-tricosadiyonol)-sn-glycerol- 3-phosphocholine forms, upon cooling below the chain melting temperature, hollow cylindrical structures known as ‘tubules’. These tubules are approximately one micron in diameter and may range from tens to hundreds of microns in length. We have carried out x-ray diffraction studies of tubules (1) in 75/25 ethanol/water by volume and (2) in a dessicated state. We present results which show marked differences in the nature of both the in-plane and inter-layer correlations associated with the wrapped multilayer structure of the tubules in the two states.