Treatment Schedule for Secondary Syphilis-Reply

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This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. To the Editor.— The query of Drs. Kaufman and Kraus was read with interest and our reply is as follows. We agree that from reading Arnold Schroeter's publication (JAMA 221:471, 1972) it is difficult to isolate those patients treated with penicillin G benzathine and to follow up their respective serologic titers over a period of two years. However, personal communication with Dr. Schroeter reaffirmed an underlying feeling of his paper, ie, that a certain percentage of individuals treated with "conventional" doses of penicillin G benzathine remain seropositive at the end of 24 months. Whether this percentage is 5% or 25% is irrelevant at this time, if it is true that larger doses of this drug could serorevert 99% or 100% of the patients. We also agree with the good doctors that, in general, serologic tests in secondary syphilis become nonreactive 12 to 18 months after treatment, but we would urge

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