Hemolytic Action of Water Soluble Compounds Related to Mephenesin

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Abstract
The hemolytic action of 16 water-soluble ethers of glycerol was examined and compared with their paralyzing and toxic action. Mephenesin was the most potent paralyzing agent and also possessed the strongest hemolytic action. The 3-o-ethoxyl-l,2-propanediol which approached mephenesin in paralyzing action, had only about half its hemolytic activity. Several other water-soluble compounds which have considerably weaker hemolytic activity were found. These compounds, however, were also much poorer paralyzing agents than mephenesin. No significant correlation between the solubility of the compounds, their water-oil partition ratios, and their paralyzing and hemolytic action was evident.