FORMATION INVIVO OF DEUTERATED METHYLTHIO METABOLITES OF NAPHTHALENE FROM L-METHIONINE (METHYL-D-3)

  • 1 January 1978
    • journal article
    • research article
    • Vol. 22  (2) , 329-343
Abstract
Deuterated methionine (methyl-d3) was studied to determine if methylthio metabolites of naphthalene were formed in vivo by reaction with methionine-derived metabolites. Rats were maintained on a methionine-free diet for 9 days followed by 8 days on the same diet supplemented with L-methionine-d3 prior to administration of naphthalene. When naphthalene metabolites isolated from urine were characterized by GC-MS [gas chromatography-mass spectrometry] and GC procedures, it was found that the incorporation of deuterium into the methylthio metabolites and into a catechol methyl ether was approximately 40%. The methyl group was derived from methionine.