Pulmonary marrow embolism: A dog model simulating dual component cemented arthroplasty
- 1 July 1987
- journal article
- research article
- Published by Springer Nature in Canadian Journal of Anesthesia/Journal canadien d'anesthésie
- Vol. 34 (4) , 336-342
- https://doi.org/10.1007/bf03010129
Abstract
The cardiopulmonary changes resulting from cemented arthroplasty procedures were monitored in 11 dogs with a single prosthesis implanted and nine dogs with a dual arthroplasty procedure. These changes were characterized by decreased BP, elevated Ppa, and elevated PVR, associated with decreases in PaO2, cardiac output and mixed venous oxygen tension. All changes were more pronounced and prolonged in the dual component arthroplasty group. Histologic lung examination and morphometry demonstrated significant degrees of marrow (fat) microembolism in the dual arthroplasty model. Cardiopulmonary collapse has been associated with Guepar dual component arthroplasties clinically and these patients are at increased risk and should be monitored continuously. Prophylactic measures include meticulous lavage of the intramedullary cavity, increased FiO2, and maintenance of intravascular volume and cardiac output. The bilateral arthroplasty model is useful in investigating therapeutic interventions which may detect and prevent the marrow microembolism syndrome intraoperatively. Les modifications cardiopulmonaires résultant ďarthroplastie avec cimeni ont été monitorées chez 11 chiens chez lesquels on avait implanté une prothèse unique et chez neuf chiens chez lesquels on avait procédé à une double arthroplastie. Les changements observés furent: diminution de la PA, augmentation de la PAP, élévation de la RVP, aussi a-t-on observé une diminution de la PaO2, du débit cardiaque et de la pression veineuse mixte en oxygène. Tous les changements furent plus prononcés et prolongés dans le groupe arthroplastie double. Ľhistologie et la morphométrie pulmonaires ont mis en évidence un degré significatif de microembolie de la moelle (graisse) dans le modèle ďarthroplastie double. En clinique le collapsus cardiovasculaire a été associé à ľarthroplastie en deux composantes de Guepar et ces patients sont à risque et devraient être monitorés de façon continue. Les mesures prophylactiques incluent: le lavage méticuleux de la cavité intramédullaire, une augmentation de ta FiO2, et le maintien du volume intravascular et du débit cardiaque. Le modèle ďarthoplastie bilatérale est utile dans ľinvestigation des interventions thérapeutiques qui pourraient détecter et prévenir le syndrome de microembolie de la moelle en peropéraloire.This publication has 23 references indexed in Scilit:
- A Monitored Cardiovascular Collapse during Cemented Total Knee ReplacementAnesthesiology, 1986
- Large Airway Response to Cemented Arthroplasty: Relationship to Hypoxaemia. An Experimental Study in DogsActa Anaesthesiologica Scandinavica, 1984
- Hemodynamic Effects of Prosthesis Insertion during Knee Replacement without TourniquetAnesthesiology, 1980
- The Ratio of Pulmonary Arterial Pressure to Pulmonary Vascular ObstructionChest, 1977
- Arterial Hypotension and Hypoxaemia During Total Hip Replacement: The Importance of Thromboplastic Products, Fat Embolism and Acrylic MonomersActa Anaesthesiologica Scandinavica, 1975
- Impaired Arterial Oxygenation Associated with Use of Bone Cement in the Femoral ShaftAnesthesiology, 1975
- Experimental Production of Vascular Hypotension, and Bone Marrow and Fat Embolism with Methylmethacrylate CementPublished by Wolters Kluwer Health ,1974
- Changes in Arterial Oxygen Tension during Total Hip ReplacementAnesthesiology, 1973
- Cardiovascular Effects of Methylmethacrylate CementBMJ, 1972
- Morphometric estimation of pulmonary diffusion capacity: IV. The normal dog lungRespiration Physiology, 1971