EFFECTIVE OUTPATIENT COMBINATION CHEMOTHERAPY FOR ADVANCED CANCER OF THE HEAD AND NECK
- 1 January 1980
- journal article
- research article
- Vol. 151 (5) , 659-662
Abstract
Patients (46) with advanced cancer of the head and neck, 42 of whom had failed conventional radiotherapy or surgical excision or both, were treated on an outpatient basis with a regimen consisting of bleomycin, methotrexate and cis-diamminedichloroplatinum II. Objective responses were noted in 29 patients. with 8 having apparent complete remissions. The median duration of partial response was only 5 mo., the median duration of complete remission was 11 mo. Median survival time for nonresponders was 4 mo., for partial responders, 6 mo., and for complete responders, 20 mo. Toxicity was acceptable. This regimen can be safely and conveniently used prior to radical excision or irradiation. The results in patients who failed to respond to prior therapy appear substantially superior to those achieved with methotrexate alone.This publication has 4 references indexed in Scilit:
- METHOTREXATE, BLEOMYCIN, AND HIGH-DOSE CIS-DICHLORODIAMMINEPLATIUM(II) IN THE TREATMENT OF ADVANCED EPIDERMOID CARCINOMA OF THE HEAD AND NECK1979
- Combination therapy of advanced head and neck cancer.Induction of remissions with diamminedichloroplatinum (II), bleomycin and radiation therapyCancer, 1978
- CIS-DICHLORODIAMMINEPLATINUM (II) IN TREATMENT OF EPIDERMOID CARCINOMA OF HEAD AND NECK1977
- Treatment of carcinoma of the head and neck with intravenous methotrexateCancer, 1968