RESPONSE: Re: Antiangiogenic Activity of Prostate-Specific Antigen
Open Access
- 16 February 2000
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 92 (4) , 345a-346
- https://doi.org/10.1093/jnci/92.4.345a
Abstract
We thank Dr. Khan for the letter regarding our early evidence for a role of prostate-specific antigen (PSA) as an endogenous antiangiogenic protein (1). Dr. Khan questions the validity of our conclusions by mentioning that the concentrations of PSA used in our experiments are not physiologic and very uncommon in humans. We agree that one should exercise caution when extrapolating in vitro bioactivity to predict potential effects in an in vivo setting. Nonetheless, we believe that our data do demonstrate the potential physiologic relevance of PSA in the regulation of tumor growth.Keywords
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