Rapid Method for the GC/MS Confirmation of 11-Nor-9-Carboxy-Δ9-Tetrahydrocannabinol in Urine
- 1 November 1984
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Analytical Toxicology
- Vol. 8 (6) , 255-259
- https://doi.org/10.1093/jat/8.6.255
Abstract
A rigorously tested simple extraction procedure for the GC/MS determination of 11-nor-Δ9-tetrahydrocannabinol 9-carboxylic acid (THC-acid) from urine is described. This assay provides sensitivity, specificity and reliability and is particularly well suited for the routine determination of large numbers of samples. The THC-acid is detected as its trimethylsilyl derivative using electron impact ionization GC/MS with an on column detection limit of below 1 ng/mL. The assay gives excellent reproducibility and linearity using the trideuterated analog of THC-acid as the internal standard. The procedure was evaluated with over 1300 samples and provided inter- and intra-day precision of 10% and 6% standard deviation, respectively.This publication has 1 reference indexed in Scilit:
- Homogeneous enzyme immunoassay for cannabinoids in urine.Clinical Chemistry, 1978