Biosynthesis of Cardiolipin in Mitochondria

1 October 1971

journal article
Published by Canadian Science Publishing in Canadian Journal of Biochemistry

Vol. 49 (10) , 1117-1124
https://doi.org/10.1139/o71-161

Abstract

Conversion of sn-glycero-3-phosphate-2-³H to cardiolipin in mitochondria isolated from guinea pig liver has been established. Cardiolipin thus formed was isolated and characterized. Under similar conditions, microsomes were not able to catalyze the biosynthesis of cardiolipin in a detectable amount. The mechanism for the biosynthesis of cardiolipin in mitochondria, similar to that described in bacteria, is suggested. These results have established mitochondrial capability to synthesize polyglycerophosphatides.

Keywords

GUINEA PIG
CARDIOLIPIN IN MITOCHONDRIA
MITOCHONDRIA CONVERSION
BIOSYNTHESIS
SIMILAR CONDITIONS
ESTABLISHED MITOCHONDRIAL
MITOCHONDRIAL CAPABILITY
SYNTHESIZE POLYGLYCEROPHOSPHATIDES

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