Cross-Resistance of Cultured Murine Leukemia Vincristine-Resistant P388 Cells to Vinblastine, Vindesine, and Bis(N-ethylidene vindesine) Disulfide, Disulfate23

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Abstract
Cultured P388 leukemia cells derived from vincristine (VCR)-resistant cell populations developed in vivo in (C57BL × DBA/2)F1 mice (P388/VCR) were cross-resistant to vinblastine (VLB), vindesine (VDS), and bis(N-ethylidene vindesine)disulfide, disulfate (bis-VDS). Cross-resistance was a function of concentration and time of exposure. Cultured P388/VCR cells were more sensitive to 6.1 × 10-5M bis-VDS than to 6.1 × 10-5M VDS or to 6.1 × 10-5M VLB. Cultured P388 cells derived from VCR-sensitive P388 leukemia passaged in vivo (P388/0) were significantly more sensitive to VDS and bis-VDS than to VLB. This degree of difference in sensitivity was also a function of concentration and time of exposure.