An Investigation into the Effects of Omeprazole on Renal Tubular Function and Endocrine Function in Man
- 1 January 1986
- journal article
- research article
- Published by Taylor & Francis in Scandinavian Journal of Gastroenterology
- Vol. 21 (sup118) , 169-170
- https://doi.org/10.3109/00365528609090932
Abstract
Omeprazole is a substituted benzimidazole which inhibits gastric acid secretion by inhibition of parietal cell H+K+ATPase. It has previously been shown (1) that it is a powerful inhibitor of gastric acid secretion in man. In animal studies, antibodies raised against H+K+ATPase cross-reacted with thyroid and thymus tissue (2). AB Hässle have reported lowered tri-iodothyronine (T3) and raised thyroid stimulating hormone (TSH) levels in laboratory animals given omeprazole in very high doses (unpublished data). In this study, the effects of omeprazole on endocrine function in male subjects were investigated, and effects on renal tubular handling of acid and electrolytes examined.Keywords
This publication has 1 reference indexed in Scilit:
- Characterization of gastric mucosal membranes. X. Immunological studies of gastric (H+ + K+)-ATPase.The Journal of cell biology, 1979