In Vitro Secondary MLR

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Abstract
With cells obtained from long-term mixed lymphocyte culture (MLC) we have demonstrated hybrid histocompatibility determinants that are recognized as mixed lymphocyte reaction (MLR)-stimulating determinants. Hybrid determinants can also be detected (1) in an in vitro assay for effector cells that measure inhibition of immunoglobulin secretion by LPS-blasts, and (2) in DTH-like responses of in vitro-primed cells injected into “B” mice and challenged in vivo with stimulator cells. The possible implications of these findings for the physiologic function of MLR determinants are discussed.

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