MORPHOLOGICAL CHANGES IN THE LATERAL VENTRICLES OF THE MOUSE BRAIN DURING GROWTH

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Abstract
In order to study the lateral ventricles of growing mice, small amounts of phthalocyanin are injected in the sub-arachnoid space of anaesthetized animals. The ventricular system is rapidly filled with stain and after fixation and clearing, a "ventricle model" obtained, which can be employed in morphological studies. Considerable changes in ventricle shape from birth to completion of growth are demonstrated. The outline of the anterior horn is changed on account of obliteration along the anterior and inferior borders. Furthermore, fusion of the ventricle walls, coarctatio, occurs in the central part and later in the anterior horn. Coarctatio is never found in newborn mice, but occurs in 96.4% of adults. It must be considered a normal process in the development of the lateral ventricles after birth. As coarctatio, which is demonstrated histologically in a number of cases, appears symmetrically and develops according to a definite pattern, it is possible on this basis to divide the ventricles into well defined types which arise in a characteristic manner in the growth period of the mouse.

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