4-NITRO-2-PHENOXYMETHANESULFONANILIDE (R-805) - CHEMICALLY NOVEL ANTI-INFLAMMATORY AGENT

  • 1 January 1976
    • journal article
    • research article
    • Vol. 221  (1) , 132-139
Abstract
The anti-inflammatory activity of the sulfonanilide, 4-nitro-2-phenoxymethanesulfonanilide (R-805) was demonstrated in conventional models (carrageenan-induced edema of the rat''s paw, UV-induced erythema of guinea pig skin, adjuvant-induced arthritis of the rat). R-805 differs from most currently available acidic anti-inflammatory drugs in that its functional acidic group is not carboxyl. The relative anti-inflammatory potency of R-805 is comparable to indomethacin. Calculation of acute therapeutic indices (LD50/ED50) for 8 acidic antiinflammatory drugs shows R-805 to possess a more favorable index than the other drugs examined.