Diamide analogues of phosphatidyl choline as potential anti-AIDS agents
- 1 January 1993
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 21,p. 2521-2523
- https://doi.org/10.1039/p19930002521
Abstract
Acylation of 3-tetrahydropyran-2-yloxypropane-1,2-diamine with dodecanoyl chloride (lauroyl chloride) and hexadecanoyl chloride (palmitoyl chloride) followed by O-deprotection afforded racemic diamide analogues of 1,2-diglycerides which were converted by sequential treatment with 2-chloro-1,3,2-dioxaphospholan-2-one and trimethylamine into the corresponding diamide analogues of phosphatidyl choline. One of these compounds shows moderate anti-HIV activity.Keywords
This publication has 0 references indexed in Scilit: