Normal cardiac rhythm during hypocaloric diets of varying carbohydrate content

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Abstract
Cardiac arrhythmias were implicated in the deaths of 17 morbidly obese individuals subsisting on a collagen hydrolysate preparation (liquid protein) during a modified fasting regimen for weight loss. Serious cardiac arrhythmias were noted in 3 of 6 subjects studied prospectively within 28 days of starting a similar regimen, which used an inadequate protein source and was nearly devoid of all essential minerals. A comparative study of three 28-day weight loss diets of varying carbohydrate, protein and energy content (450-820 kcal/day) but employing protein of good quality and adequate in micronutrients did not disclose substantial diet-related arrhythmias in 5 subjects on each of the 3 diets. The incidence of arrhythmia seen with liquid protein diets is not likely to be related to the absolute energy or carbohydrate content of the modified fasting regimen itself.

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