Synthesis of (R)-(–)- and (S)-(+)-muscone of 100% optical purity by conjugate addition of chiral methylcuprate to (E)-cyclopentadec-2-enone
- 1 January 1991
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 2,p. 101-102
- https://doi.org/10.1039/c39910000101
Abstract
Synthesis of (R)-(–)- and (S)-(+)-muscone of essentially 100% enantiomeric excess (e.e.) by the conjugate addition of chiral methylcuprate to (E)-cyclopentadec-2-enone was accomplished by adding small amounts of tetrahydrofuran (THF) as an external ligand to a toluene solution of the chiral methylcuprate.Keywords
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