NUP98 Is Fused to Topoisomerase (DNA) IIβ 180 kDa (TOP2B) in a Patient with Acute Myeloid Leukemia with a New t(3;11)(p24;p15)
Open Access
- 15 September 2005
- journal article
- case report
- Published by American Association for Cancer Research (AACR) in Clinical Cancer Research
- Vol. 11 (18) , 6489-6494
- https://doi.org/10.1158/1078-0432.ccr-05-0150
Abstract
Purpose: The nucleoporin 98 kDa (NUP98) gene has been reported to be fused to 17 different partner genes in various hematologic malignancies with 11p15 aberrations. Cytogenetic analysis of an adult de novo acute myelogenous leukemia (M5a) revealed a t(3;11)(p24;p15), suggesting rearrangement of NUP98 with a novel partner gene.Keywords
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