Histaminergic and Serotonergic Receptor Blocking Substances from the Medicinal PlantGarcinia mangostana

Publisher Website
Google Scholar
Abstract
A crude methanolic extract of the fruit hull of Mangosteen, Garcinia mangostana L. inhibited the contractions of isolated thoracic rabbit aorta induced by histamine and serotonin. The extract of the fruit hull has been fractionated by silica gel chromatography, monitoring the pharmacological activity to give α- and γ-mangostin. On the basis of pharmacological data, it is suggested that α-mangostin and γ-mangostin are a histaminergic and a serotonergic receptor blocking agent, respectively.

This publication has 0 references indexed in Scilit: