Effects of Androgen Treatment on Adenylate Cyclase System in Rat Hepatic Membranes
- 1 June 1992
- journal article
- Published by Wiley in Basic & Clinical Pharmacology & Toxicology
- Vol. 70 (6) , 429-433
- https://doi.org/10.1111/j.1600-0773.1992.tb00502.x
Abstract
Effects of androgen treatment of young female rats on glucagon‐ and catecholamine‐sensitive adenylate cyclase activity and adrenergic receptors of hepatic membranes have been studied. Injections of testosterone propionate for 7 days showed a significant decrease in the adenylate cyclase activity responding to isoproterenol and glucagon. The decrease in hormonal stimulation of the enzyme was accompanied with the fall in activation by non‐hormonal stimuli, such as forskolin, sodium fluoride, Gpp(NH)p and Mn, without any changes in the number and the affinity of p‐adrenergic receptors of the membrane. These results suggest that androgens exert post‐receptor effects by inhibiting the activity of the catalytic unit of adenylate cyclase system in rat hepatic membranes.Keywords
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