Nodular Renal Blastema, Renal Dysplasia and Duplicated Collecting Systems

Abstract
The association of nodular renal blastema, renal dysplasia and duplicated collecting systems may represent more than a histopathological observation. Based on the "double hit" theory of oncogenesis, the appearance of this histologic pattern in kidneys with other developmental alterations may account for an increased risk of neoplasia.