Influence of tetrodotoxin and calcium on changes in extracellular dopamine levels evoked by systemic nicotine

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Abstract
The influence of tetrodotoxin (TTX) and calcium on the increase of extracellular dopamine (DA) levels in the nucleus accumbens (NAcc), evoked by the systemic administration of nicotine, cocaine andd-amphetamine, have been studied in conscious, freely moving rats using in vivo microdialysis. TTX (10−6 M), administered via the dialysis probe, completely abolished (P−4 M) in the Ringer solution was also associated with inhibition (Pd-amphetamine (0.5 mg/kg SC) caused elevations in extracellular DA (PPPd-amphetamine treatment. The presence of TTX and removal of calcium with addition of EDTA completely abolished the changes in NAcc DA and HVA induced by cocaine. TTX had no influence on thed-amphetamine evoked responses in NAcc DA. However, the metabolites, which were markedly reduced by the TTX, were not further decreased by the systemic administration ofd-amphetamine. NAcc DA was significantly (Pd-amphetamine in the absence of calcium and presence of EDTA. However, this was significantly (Pd-amphetamine-induced stimulation of this system in vivo.