Acute effects of massive transfusion of a bovine hemoglobin blood substitute in a canine model of hemorrhagic shock

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Abstract
The capability of stroma-free hemoglobin solutions to act as a plasmaexpander with oxygen and carbon dioxide transport properties has encouragedthe idea of their possible use in settings of massive blood loss. Using acanine hemorrhagic shock model (systolic arterial pressure < or = 50torr for 60 min), we evaluated the efficacy of an ultra-pure stroma-freebovine hemoglobin solution (PBHg) as a resuscitation fluid in hypovolemicand acidotic animals, using homologous blood (PRBC) and 10% human serumalbumin (HSA) as control solutions. Following volume replacement, dogs werestudied for 2 h under anesthesia and for 4 h subsequently while awake.Resuscitation with PBHg (30 +/- 3 ml/kg) was able to restore stablehemodynamics and correct acidosis to an extent comparable to that inanimals treated with PRBC. Additionally, oxygen transport was maintained ata higher level than that in dogs treated with HSA. Administration of PBHgin this shock model revealed no significant cardiopulmonary toxicity oradverse effects. These short-term results suggest that PBHg may be usefulfor effective resuscitation after major blood loss.

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