Resistance to Collagen‐Induced Arthritis in Biozzi Mice is Not Associated With a Defect in Autoantibodies to Accessible Epitopes on Cartilage Collagen

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Abstract
In order to understand why most strains of Biozzi mice are unexpectedly either arthritis-resistant, or susceptible, we investigate the autoantibody reactivity against matrix-embedded collagen molecules. We show a close correlation between these tissular and the free collagen antibodies, irrespective of arthritis susceptibility. These results are against an antibody response restricted to hidden non-pathogenic epitopes in the resistant mice.