A New Method for the Preparation of 2-Methyl-1-(2-oxoalkyl)-1,2,3,4-tetrahydroisoquinolines
- 1 January 1988
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1988 (12) , 1001-1003
- https://doi.org/10.1055/s-1988-27786
Abstract
1-Ethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline (3a) has been prepared by the reaction of 2-methyl-3,4-dihydroisoquinolinium bromide (7a) with sodium ethoxide. A convenient method for the preparation of 2-methyl-1-(2-oxoalkyl)-1,2,3,4-tetrahydroisoquinolines 2 has been developed by utilizing the nucleophilic reaction of active methylene compounds with 3a.Keywords
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