The 16-18 Trisomy Syndrome
- 1 February 1963
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Pediatrics & Adolescent Medicine
- Vol. 105 (2) , 213-215
- https://doi.org/10.1001/archpedi.1963.02080040215015
Abstract
With recent technical advances, chromosome studies have become increasingly practical and useful. Two clinical syndromes associated with an extra chromosome in either the 13-15 (D) group1,2or the 16-18 (E) group3-6have been documented. The multiple congenital anomalies associated with these 2 trisomic states are apparently so severe that few of those affected survive. Thus, recognition of the clinical picture with confirmation by cytogenetic studies can provide significant prognostic information. Report of a Case The patient was born Aug. 14, 1961, in another hospital via elective cesarean section. The mother appeared full term, but at section had marked polyhydramnios. The birth weight was 4 lb. 4¼oz. (about 1,935 gm.); length was 17.5 in.; head circumference 12.5 in., and chest circumference 11.5 in. It was promptly noted that the infant had a high-pitched cry and a peculiar combination of physical abnormalities. Those listed were (1) first toe onKeywords
This publication has 1 reference indexed in Scilit:
- Chromosome preparations of leukocytes cultured from human peripheral bloodExperimental Cell Research, 1960