Contact Regions in the Dimer of Alzheimer β-Amyloid Domain [1–28] Studied by Mass Spectrometry
- 1 April 2004
- journal article
- Published by SAGE Publications in European Journal of Mass Spectrometry
- Vol. 10 (2) , 309-316
- https://doi.org/10.1255/ejms.642
Abstract
Information is provided about the amino acid residues in the [1–28] domain of the Alzheimer β-amyloid protein, which participate in interstrand pairing and initiate fibillogenesis. The study was carried out using electrospray ionization on a four sector mass spectrometer, measuring kinetic energy release for a fragmentation process, and modeling the transition state with molecular dynamics calculations. The results eliminate the sequence [11–24] proposed earlier as the central core, and are consistent with, but do not distinguish between, residues [17–28] and [17–23] proposed by others based on biochemical studies.Keywords
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