Maturation of Bursal Stem Cells within Allogeneic or Syngeneic Bursal Microenvironment: Surface Determinants and Capacity for Germinal Centre Formation

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Abstract
Maturation of [chicken] bursal stem cells in an allogeneic environment was studied. The occurrence of surface Ig[immunoglobulin]M, surface IgG and Ia-like antigens on B [bursa-derived] cells after differentiation within an allogeneic bursa was studied. The immediate capacity of B cells to form germinal centers after differentiation in an allogeneic bursa was studied by injecting them with histocompatible T [thymus-derived] cells into test-tube birds. The switch to surface-IgG-bearing cells occurs in an allogeneic bursa in a similar manner as in a syngeneic bursa. Studies of the occurrence of Ia-like antigens on bursa cells show that they retain their original Ia-like antigens even during maturation in an allogeneic host. After differentiation within an allogeneic environment bursa cells have the immediate capacity to cooperate with histocompatible T cells as measured by germinal center formation in test-tube birds.