EFFECTS OF SELECTIVE AND NON-SELECTIVE BETA-ADRENERGIC AGENTS ON RENIN SECRETION IN ISOLATED PERFUSED RAT-KIDNEY

  • 1 January 1980
    • journal article
    • research article
    • Vol. 212  (1) , 34-38
Abstract
The effects of selective and nonselective .beta.-adrenergic drugs on the renin secretion rate (RSR) in isolated perfused rat kidneys were studied. Both isoproterenol (Ipr) (nonselective agonist) and salbutamol (Salb) (.beta.-2 selective agonist) stimulated RSR in a dose-dependent manner. The lowest doses able to induce a significant RSR increase were 5 nM for Ipr and 50 nM for Salb. A 5-fold increase in RSR was induced by 500 nM Ipr and a 3.2-fold increase by 5 .mu.M Salb. Renin stimulation by both agonists was suppressed by propranolol (nonselective) and by acebutolol and its derivative M&B 16,942 [RS-1-(2-acetyl-4-acetamidophenoxy)-2-hydroxy-3-isopropylaminopropane] (.beta.-1 selective antagonists). Renin release was stimulated or inhibited effectively by all drugs tested, regardless of the .beta. selectivity of agonists and antagonists. There were no consistent relationships between changes in renal hemodynamics and in RSR, suggesting that the drugs affected renin release from in vitro-perfused rat kidney through their direct effects on juxtaglomerular cells. Renal .beta.-adrenoreceptors involved in renin release do not fall into 2 distinct .beta. subtypes.