SIMMONDS' DISEASE (ANTERIOR HYPOPHYSIAL INSUFFICIENCY)

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Abstract
Because of the current interest in diseases of the endocrine glands and because of the comparative sparsity of reports of cases of Simmonds' disease with autopsy, the following cases are placed on record. There is included also a comparison of some of the effects of the glandular deficiency of Simmonds' disease and of the glandular hyperfunction of acromegaly. REPORT OF CASES Case 1. —A 51 year old housewife was admitted to the Cleveland City Hospital on April 10, 1935, in coma. Clinical History. —The clinical history was obtained from the records of the University Hospital Dispensary, where the patient was first seen on June 8, 1933. She complained then only of pain and stiffness of the knees, which were worse after disuse and improved with exercise. These symptoms began three years previously, after six months of convalescence from a difficult delivery. The menses, which had been normal, had stopped, and

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