Remote Stereocontrol in Ketene-Imine Cycloaddition: An Efficient Asymmetric Synthesis ofcis-β-Lactams
- 1 January 1992
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1992 (09) , 749-750
- https://doi.org/10.1055/s-1992-21480
Abstract
Annelation of imines 4-6 derived from a homochiral bicyclic aldehyde, 3,6,6-trimethylbicyclo[3.1.0] hex-2-ene-2-carbaldehyde, with acid chlorides or equivalent 1-3 and triethylamine provided cis-ß-lactams 7 and 8a-i in excellent yields with high diastereoselectivity.Keywords
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