Restoration of Prostacyclin/Thromboxane A2 Balance in the Diabetic Rat: Influence of Dietary Vitamin E
- 1 November 1982
- journal article
- Published by American Diabetes Association in Diabetes
- Vol. 31 (11) , 947-951
- https://doi.org/10.2337/diacare.31.11.947
Abstract
The effect of dietary vitamin E on the synthesis of platelet thromboxane A2 (TxA2) and vascular prostacyclin (PGI2) in streptozotocin-induced diabetic rats was investigated. Thrombin-induced platelet TxA2 synthesis in diabetic rats was significantly elevated, whereas no significant difference was found with collagen-induced synthesis. Arterial PGI2 production was significantly decreased in diabetic rats. Serum lipid peroxide levels were elevated, and platelet vitamin E levels decreased in diabetic rats. When the diabetic rats were maintained on a high vitamin E diet for 2-3 mo, thrombin-induced platelet TxA2, vascular PGI2, and lipid peroxides were restored to levels found in nondiabetic rats. Platelets from diabetic rats maintained on a high vitamin E diet synthesized significantly less collagen-induced TxA2 than platelets from nondietary vitamin E-supplemented diabetic rats or nondiabetic controls.Keywords
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